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. 2020 Apr 28;10:7162. doi: 10.1038/s41598-020-64195-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of Ramucirumab and/or Paclitaxel on cell cycle progression in gastric cancer cell lines. (a) AGS, NCI-N87 [N87], HGC-27 and KATO III human gastric cancer cells were synchronized in the G2/M phase of the cell cycle (T0). 1 nM Paclitaxel and 100 μg/ml Ram alone or in combination were administrated to a subgroup of cells processed after 3 h from block release (T1). The percentage of cells in the subsequent G0/G1 phase was evaluated and plotted in the graphs. The results of three independent experiments, expressed as mean ± SD, were plotted in the relative graphs. *p < 0.05; **p < 0.001; ***p < 0.0001. (b) The expression of activated cdc25A, cdc2, Cyclin B1, c-myc and STAT3 was analyzed in AGS and KATO III cells after 48 h of Ram and/or PTX treatment. Three independent experiments were performed and a representative Western Blotting image is shown.