Table 1.

TCM for treating AD by reducing β-Amyloid production.

Numbers	Compounds	Chemistry structure	Dosages	Activities	Molecular mechanism	Models	References
1	Ginseng protein	—	0.05–0.1 g/kg twice daily	Improve the memory ability and cognitive and reduce Aβ production	Inhibit Aβ1-42 and p-tau and increase the mRNA and PI3K, p-Akt/Akt, and Bcl-2/Bax	d-galactose/AlCl3 induced rat model	Li et al., 2016a
2	Dracoephalum moldavica L. flavonoid	—	200 mg/kg	Reduce Aβ deposition and insoluble Aβ levels	Attenuate Aβ-induced toxicity through anti-amyloidogenesic and neurotrophic pathways	Heterozygous APPswe/PS1Δ9 transgenic founder mice	Liu et al., 2018
3	Safflower yellow		10–30 mg/kg	Improve cognitive function and ameliorate the learning and memory deficits	Decrease Aβ accumulation and overactivation of astrocytes	APP/PS1 transgenic mice	Ma et al., 2015
4	Emodin		80 mg/kg/day	Improve the memory ability and cognitive, reduce Aβ production	Reduce the levels of Aβ and tau phosphorylation	Hyperhomocysteinemia (HHcy) induced rats	Zeng et al., 2019
5	Onjisaponin B		1mg/mL, 200μL	Suppress Aβ production, improve learning and memory capacity	Suppress Aβ production promoted the degradation of APP	The APPswe/PS1ΔE9 (APP/PS1) double-transgenic mice	Li et al., 2016a