Table 2.
TCM for treating AD by anti-apoptosis.
| Numbers | Compounds | Chemistry structure | Dosages | Activities | Molecular mechanism | Models | References |
|---|---|---|---|---|---|---|---|
| 1 | Morroniside |
|
100 μM | Inhibit apoptosis | Inhibit apoptosis via attenuating JNK and p38 MAPK phosphorylation | PC12 cells | Chen et al., 2018b |
| 2 | Curcumin |
|
12.5–200 μM | Reversal neurotoxicity, inhibit apoptosis | Inhibit apoptosis though p38 MAPK and AKT pathways | PC12 cells | Uğuz et al., 2016; Fan et al., 2017 |
| 3 | Triptolide |
|
10−11 mol/L | Inhibit apoptosis | Inhibit intracellular Ca2+ and apoptosis | PC12 cells | Gu et al., 2004; Wang et al., 2015a; Xu et al., 2016 |
| 4 | Crocin |
|
40 mg/kg | Regulate endoplasmic reticulum stress and apoptosis | Increase the autophagy and apoptosis biomarkers | Male Wistar rats | Asadi et al., 2015; Lin et al., 2019a; Lin et al., 2019b; Mohammadzadeh et al., 2019 |