Table 3. Stratified analysis on the association of depression within 3 years before dyslipidemia diagnosis on cardiovascular disease according to subgroups of statin medication compliance.
| Variable | Adjusted hazard ratio (95% confidence interval)a | |||||
|---|---|---|---|---|---|---|
| Cardiovascular disease | Coronary heart disease | Stroke | ||||
| No depression | Depression | No depression | Depression | No depression | Depression | |
| Total | ||||||
| MPR ≥0.8 | 1.00 (reference) | 1.42 (1.06–1.90) | 1.00 (reference) | 1.40 (0.94–2.08) | 1.00 (reference) | 1.35 (0.89–2.04) |
| MPR 0.5–0.7 | 1.00 (reference) | 1.17 (0.91–1.52) | 1.00 (reference) | 1.12 (0.79–1.59) | 1.00 (reference) | 1.10 (0.76–1.59) |
| MPR <0.5 | 1.00 (reference) | 1.25 (1.05–1.50) | 1.00 (reference) | 1.14 (0.88–1.47) | 1.00 (reference) | 1.29 (1.01–1.65) |
| Men | ||||||
| MPR ≥0.8 | 1.00 (reference) | 1.77 (1.14–2.74) | 1.00 (reference) | 1.71 (0.98–3.00) | 1.00 (reference) | 1.89 (1.00–3.60) |
| MPR 0.5–0.7 | 1.00 (reference) | 1.15 (0.74–1.81) | 1.00 (reference) | 0.89 (0.48–1.68) | 1.00 (reference) | 1.44 (0.78–2.65) |
| MPR <0.5 | 1.00 (reference) | 1.03 (0.73–1.46) | 1.00 (reference) | 0.93 (0.59–1.46) | 1.00 (reference) | 1.19 (0.73–1.93) |
| Women | ||||||
| MPR ≥0.8 | 1.00 (reference) | 1.22 (0.82–1.80) | 1.00 (reference) | 1.15 (0.65–2.03) | 1.00 (reference) | 1.11 (0.65–1.92) |
| MPR 0.5–0.7 | 1.00 (reference) | 1.19 (0.87–1.63) | 1.00 (reference) | 1.28 (0.84–1.96) | 1.00 (reference) | 0.95 (0.60–1.52) |
| MPR <0.5 | 1.00 (reference) | 1.33 (1.08–1.65) | 1.00 (reference) | 1.24 (0.91–1.69) | 1.00 (reference) | 1.32 (0.99–1.75) |
MPR, medication possession ratio.
aHazard ratio calculated by Cox proportional hazards regression analysis after adjustments for age, sex, household income, smoking, physical activity, alcohol consumption, body mass index, systolic blood pressure, total cholesterol, fasting serum glucose, Charlson comorbidity index, and index year.