Table 3.
Characteristics of the mice used in this study.
| Months | Sex | Genotype | Mass (g) | IWAT:bw (x10∧2) | GWAT:bw (x10∧2) | BAT:bw (x10∧2) | GLUCOSE (MG/Dl) |
|---|---|---|---|---|---|---|---|
| HIGH FAT DIET | |||||||
| 1 | M | –rtTA | 47.2 ± 5.4 | 1.7 ± 0.50 | 1.2 ± 0.70 | 0.7 ± 0.10 | 135.1 ± 41.3 |
| M | +rtTA | 37.3 ± 4.7 | 0.8 ± 0.30 | 1.2 ± 0.13 | 0.7 ± 0.06 | 84.60 ± 16.1 | |
| F | –rtTA | 24.4 ± 5.7 | 0.9 ± 0.28 | 1.3 ± 0.12 | 0.9 ± 0.32 | 156.2 ± 22.5 | |
| F | +rtTA | 24.2 ± 6.0 | 0.9 ± 0.35 | 1.3 ± 0.10 | 0.8 ± 0.10 | 141.5 ± 22.9 | |
| 2 | M | –rtTA | 35.8 ± 5.8 | 0.8 ± 0.20 | 1.7 ± 0.37# | 0.1 ± 0.05 | 117.5 ± 30.9 |
| M | +rtTA | 30.7 ± 1.8 | 1.3 ± 0.40 | 1.3 ± 0.08 | 0.9 ± 0.10 | 94.60 ± 28.5 | |
| F | –rtTA | 31.0 ± 5.9 | 1.0 ± 0.10 | 1.3 ± 0.13 | 0.8 ± 0.60 | 88.00 ± 2.40 | |
| F | +rtTA | 35.6 ± 2.4 | 0.7 ± 0.07 | 1.5 ± 0.42 | 1.0 ± 0.60 | 99.50 ± 14.2 | |
| 3 | M | –rtTA | 48.8 ± 3.1 | 2.8 ± 0.10 | 1.7 ± 0.01# | 1.6 ± 0.23*# | 172.0 ± 43.3 |
| M | +rtTA | 54.2 ± 1.7 | 2.0 ± 0.70 | 1.6 ± 0.03 | 0.9 ± 0.32 | 193.5 ± 19.1 | |
| F | –rtTA | 29.6 ± 4.7 | 0.3 ± 0.05 | 1.4 ± 0.30 | 0.9 ± 0.02 | 94.60 ± 4.90 | |
| F | +rtTA | 28.4 ± 4.3 | 0.9 ± 0.30 | 1.4 ± 0.20 | 0.9 ± 0.40 | 117.6 ± 17.8 | |
| 4 | M | –rtTA | 42.4 ± 4.7 | 1.7 ± 0.80 | 1.7 ± 0.70# | 1.6 ± 0.10# | 98.00 ± 21.1 |
| M | +rtTA | 43.6 ± 8.1* | 1.5 ± 0.50 | 1.6 ± 0.12 | 1.3 ± 0.32# | 88.20 ± 1.70 | |
| F | –rtTA | 35.4 ± 5.4 | 1.6 ± 0.10 | 1.9 ± 0.20# | 1.3 ± 0.45 | 97.30 ± 11.4 | |
| F | +rtTA | 33.3 ± 7.6 | 0.9 ± 0.20 | 1.9 ± 0.09# | 1.3 ± 0.44 | 86.80 ± 44.5 | |
| CHOW DIET | |||||||
| 1 | M | –rtTA | 32.2 ± 5.2 | 1.2 ± 1.1 | 1.1 ± 0.44 | 1.3 ± 0.13 | 144.1 ± 28.5 |
| M | +rtTA | 34.2 ± 0.9 | 0.9 ± 0.04 | 1.3 ± 0.60 | 0.9 ± 0.30 | 117.3 ± 30.9 | |
| F | –rtTA | 21.4 ± 1.6 | 0.5 ± 0.10 | 1.1 ± 0.86 | 0.8 ± 0.30 | 118.2 ± 19.6 | |
| F | +rtTA | 22.2 ± 0.6 | 0.5 ± 0.19 | 1.3 ± 0.08 | 1.1 ± 0.11 | 116.2 ± 12.6 | |
| 2 | M | –rtTA | 43.4 ± 10 | 1.2 ± 0.30 | 1.3 ± 0.09 | 0.9 ± 0.2.1 | 104.4 ± 21.3 |
| M | +rtTA | 36.6 ± 17 | 1.5 ± 0.01 | 1.4 ± 0.77 | 0.1 ± 0.30 | 123.6 ± 23.7 | |
| F | –rtTA | 21.2 ± 2.4 | 0.5 ± 0.20 | 1.2 ± 0.03 | 0.8 ± 0.02 | 87.20 ± 25.9 | |
| F | +rtTA | 23.0 ± 1.4 | 0.6 ± 0.20 | 1.4 ± 0.1.1 | 0.9 ± 0.04 | 93.20 ± 22.7 | |
| 3 | M | –rtTA | 34.2 ± 3.7 | 0.6 ± 0.05 | 1.7 ± 0.40# | 1.2 ± 0.01 | 129.6 ± 15.9 |
| M | +rtTA | 34.2 ± 5.5 | 1.1 ± 0.34 | 1.4 ± 0.60 | 0.1 ± 0.12 | 142.6 ± 31.4 | |
| F | –rtTA | 22.3 ± 2.6 | 0.5 ± 0.20 | 1.5 ± 0.01 | 0.7 ± 0.43 | 93.40 ± 27.7 | |
| F | +rtTA | 23.9 ± 3.4 | 0.6 ± 0.20 | 1.4 ± 0.02 | 1.1 ± 0.90 | 101.8 ± 18.2 | |
| 4 | M | –rtTA | 22.1 ± 2.3 | 1.4 ± 0.76 | 1.8 ± 0.30# | 1.3 ± 0.20 | 126.3 ± 4.10 |
| M | +rtTA | 27.6 ± 6.1 | 1.4 ± 0.70 | 1.5 ± 0.01* | 1.0 ± 0.12 | 136.3 ± 2.50 | |
| F | –rtTA | 28.2 ± 5.0 | 1.0 ± 0.60 | 1.5 ± 0.20 | 0.7 ± 0.40 | 94.90 ± 19.0 | |
| F | +rtTA | 29.1 ± 3.9 | 1.4 ± 0.20* | 1.6 ± 0.20 | 1.2 ± 0.32 | 107.6 ± 27.4 | |
Values represent the mean ± SD. IWAT, inguinal white adipose tissue; GWAT, gonadal white adipose tissue; BAT, brown adipose tissue; bw, body weight. Glucose levels were measured in the fasted state, 30 min following insulin injection. *indicates significant difference between genotypes, # indicates significant difference from 1-month.