Table 3.

Substrate scope of the reaction with indoles.^a

Indoles	Trifluoromethly substituted hydroxylakylated indoles	Mp (°C)	Purity (%)b	Yield (%)c
1b	3p	122–124 (75)d [25]	98	96 (95)e [25]
1c	3q	160–161	99	79
1d	3r	192–193	97	90
1e	3s	112–113	99	94 (98)e [24]
1f	3t	90–91 (90)d [24]	99	96 (98)e [24]
1g	3u	165–166	98	91
1h	3v	227–228	97	92
1i	3w	239–240	99	97
1j	3x	185–186 185d [24]	97	90 86e [24]

^aReaction conditions: 1 (3.4 mmol) and 2 (3.75 mmol) in water (5 mL). ^bPurity was determined by HPLC coupled to a UV diode array detector (DAD) at 220−400 nm. ^cIsolated yields. ^dReported melting points. ^eReported yields.