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T1-Weighted sagittal magnetic resonance images revealing leptomeningeal tumors in rat spinal cord (gray arrowhead) before ultrasound and microbubble treatment (left column), and the enhancement of the cord indicating blood–spinal cord barrier opening (white arrows) after ultrasound and microbubble treatment (right column). Reprinted (adapted) with permission from O'Reilly et al. (2018).
