Fig. 7.

Histologic sections of a coronary artery of a pig 28 d after angioplasty. Pigs were treated with sirolimus-loaded microbubbles only (a) or sirolimus-loaded microbubbles and ultrasound (b) using a mechanically rotating intravascular ultrasound catheter (5 MHz, 500 cycles, 50% duty cycle, 0.6 MPa peak negative pressure). Treatment with ultrasound and sirolimus-loaded microbubbles reduced neointimal formation by 50%. In both sections, the intima (I) and media (M) are outlined. Bar = 500 µm. Reprinted with permission from Springer Nature: Springer, Annals of Biomedical Engineering, Reducing Neointima Formation in a Swine Model with IVUS and Sirolimus Microbubbles, Kilroy JP, Dhanaliwala AH, Klibanov AL, Bowles DK, Wamhoff BR, Hossack JA, COPYRIGHT, from Kilroy JP et al. (2015).