Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 28;10:7187. doi: 10.1038/s41598-020-64236-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effects of CB1R agonist and NO donor on eIPSCs in the insular cortex. (a) 3 μM ACEA decreased eIPSC amplitudes (n = 8). (b) Summary scatter plots of PPF before (Control) and during application of 3 μM ACEA (n = 10). ACEA increased PPF. (c) 200 μM SNAP increased eIPSC amplitudes (n = 8). (d) Summary scatter plots of PPF before (Control) and during application of 200 μM SNAP (n = 10). SNAP decreased PPF. (e) In the presence of 3 μM ACEA, 200 μM SNAP had no effect on eIPSC amplitudes (n = 8). (f) In the presence of 200 μM SNAP, 3 μM ACEA markedly decreased eIPSC amplitudes (n = 7). (g) In the presence of 100 μM L-NAME, 3 μM ACEA had no effect on amplitude of eIPSCs (n = 9). (h) Summary scatter plots of eIPSCs obtained from the experiments shown in (a,c,e–g). Paired t-test, *p < 0.02 compared to control response. Unpaired t-test, ^#p < 0.01. (i) In the presence of 100 μM L-NAME, LTP_GABA caused by the prolonged HFS was completely abolished (n = 8). The insets show averages of ten consecutive current traces before (pre) and 25–30 min after the prolonged HFS (post). The prolonged HFS is indicated by an arrow. (a,c,e–g) The insets show averages of ten consecutive current traces before and 15–20 min after drug applications. (a-g,i) Scale bar represents 50 pA and 50 ms.