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. 2020 Apr 28;10:7187. doi: 10.1038/s41598-020-64236-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Leptin unmasks LTP_GABA. (a) In the presence of 10 nM leptin, LTP_GABA was induced by the prolonged HFS (n = 8). (b) Summary scatter plots of PPF before and after the prolonged HFS in the presence of 10 nM leptin (n = 9). Leptin decreased PPF. (c) Leptin (10 nM) had no effect on eIPSCs (n = 9). The insets show averages of ten consecutive current traces before (Control) and 15–20 min after leptin application. (d) In the presence of 10 nM leptin and 100 μM L-NAME, the prolonged HFS had no effect on eIPSC amplitudes (n = 8). (e) In the presence of 10 nM leptin and 10 μM AG490, the prolonged HFS induced LTD_GABA (n = 8). (f) In the presence of 10 nM leptin and 200 nM wortmannin, the prolonged HFS induced LTD_GABA (n = 12). (g) In the presence of 10 nM leptin and 10 μM PD98059, the prolonged HFS induced LTD_GABA (n = 10). (h) Summary scatter plots of eIPSCs obtained from the experiments shown in (a,d–g). Paired t-test, *p < 0.04 compared to control response. (a,c–g) The insets show averages of ten consecutive current traces before (pre) and 25–30 min after HFS (post). (a,d–g) The prolonged HFS is indicated by an arrow. (a–g) Scale bar represents 50 pA and 50 ms.