Table 1.
Demographic and genetic characteristics in patients with exudative ag-related macular degeneration.
| All patients (n = 234) | Typical neovascular AMD (n = 118) | PCV (n = 116) | P value | |
|---|---|---|---|---|
| Age | 74.9 ± 8.2 | 77.5 ± 8.0 | 72.2 ± 7.7 | 3.5 × 10−6 |
| Male gender | 170 (72.7%) | 80 (67.8%) | 90 (77.6%) | 0.093 |
| Need for retreatment | 157 (67.1%) | 81 (68.6%) | 76 (65.5%) | 0.31 |
| Baseline BCVA (log MAR) | 0.42 ± 0.37 | 0.51 ± 0.38 | 0.33 ± 0.33 | 4.0 × 10−4 |
| ARMS2 A69S (rs10490924) | ||||
| TT | 100(42.7%) | 60(50.9%) | 40(34.5%) | |
| TG | 95(40.6%) | 44(37.2%) | 51(44.0%) | |
| GG | 39(16.7%) | 14(11.9%) | 25(21.5%) | |
| T allele frequency | 63.0% | 69.5% | 56.5% | 3.5 × 10−3 |
| CFH I62V (rs800292) | ||||
| GG | 134(57.3%) | 71(60.2%) | 63(54.3%) | |
| GA | 88(37.6%) | 42(35.6%) | 46(39.7%) | |
| AA | 12(5.1%) | 5(4.2%) | 7(6.0%) | |
| G allele frequency | 76.1% | 78.0% | 74.1% | 0.016 |
| CFH (rs1329428) | ||||
| CC | 101(43.2%) | 52(44.1%) | 49(42.2%) | |
| CT | 108(46.2%) | 59(50.0%) | 49(42.2%) | |
| TT | 25(10.6%) | 7(5.9%) | 18(15.6%) | |
| C allele frequency | 66.2% | 69.1% | 63.4% | 0.19 |
| C2-CFB-SKIV2L (rs429608) | ||||
| AA | 2(0.9%) | 0 | 2(1.7%) | |
| AG | 33(14.1%) | 13 (11.0%) | 20(17.2%) | |
| GG | 199(85.0%) | 105(89.0%) | 94(81.1%) | |
| A allele frequency | 7.9% | 5.5% | 10.3% | 0.053 |
| C3 (rs2241394) | ||||
| GG | 1(0.4%) | 0 | 1(0.9%) | |
| GC | 27(11.5%) | 14(11.9%) | 13(11.2%) | |
| CC | 206(88.0%) | 104(88.1%) | 102(87.9%) | |
| G allele frequency | 6.2% | 5.9% | 6.5% | 0.81 |
| CETP (rs3764261) | ||||
| TT | 10(4.3%) | 5(4.2%) | 5(4.3%) | |
| TG | 70(29.9%) | 33(28.0%) | 37(31.9%) | |
| GG | 154(65.8%) | 80(67.6%) | 74(63.8%) | |
| T allele frequency | 19.2% | 18.2% | 20.3% | 0.58 |
| ADAMTS9 (rs6795735) | ||||
| CC | 4(1.7%) | 1(0.8%) | 3(2.6%) | |
| CT | 55(23.5%) | 29(24.6%) | 26(22.4%) | |
| TT | 175(74.8%) | 88(74.6%) | 87(75.0%) | |
| C allele frequency | 13.5% | 13.1% | 13.8% | 0.84 |