Table 2.
Comparison of genetic characteristics between patients with or without retreatment.
| With retreatment (n = 157) | Without retreatment (n = 77) | Univariate p-value | Multivariate p-value | Odds ratio (95%CI) | |
|---|---|---|---|---|---|
| Age | 76.2 ± 7.8 | 72.1 ± 8.5 | 3.5 × 10−6 | 5.2 × 10−4(※) | 1.06 (1.03–1.10) |
| Male gender | 113(72.0%) | 57(74.0%) | 0.74 | NA | NA |
| AMD subtype (neovascular AMD) | 81(51.6%) | 37(48.1%) | 0.61 | NA | NA |
| ARMS2 A69S (rs10490924) | |||||
| TT | 77(49.0%) | 23(29.9%) | |||
| TG | 63(40.1%) | 32(41.6%) | |||
| GG | 17(10.9%) | 22(28.5%) | |||
| T allele frequency | 69.1% | 50.6% | 1.0 × 10−4 | 2.0 × 10−4(※※) | 2.18 (1.47–3.24) |
| CFH I62V (rs800292) | |||||
| GG | 96(61.1%) | 38(49.4%) | |||
| GA | 55(35.0%) | 33(42.9%) | |||
| AA | 6(3.8%) | 6(7.3%) | |||
| G allele frequency | 78.7% | 71.2% | 0.060 | NA | NA |
| CFH (rs1329428) | |||||
| CC | 75(47.8%) | 26(33.7%) | |||
| CT | 71(45.2%) | 37(48.1%) | |||
| TT | 11(7.0%) | 14(18.2%) | |||
| C allele frequency | 71.3% | 57.6% | 6.8 × 10−3 | 2.0 × 10−3(※※) | 1.74 (1.16–2.59) |
| C2-CFB-SKIV2L (rs429608) | |||||
| AA | 1(0.6%) | 1(1.3%) | |||
| AG | 21(13.4%) | 12(15.6%) | |||
| GG | 135(86.0%) | 64(83.1%) | |||
| A allele frequency | 7.5% | 7.6% | 0.51 | NA | NA |
| C3 (rs2241394) | |||||
| GG | 0 | 1(1.3%) | |||
| GC | 16(10.2%) | 11(14.3%) | |||
| CC | 141(89.8%) | 65(84.4%) | |||
| G allele frequency | 4.5% | 7.6% | 0.16 | NA | NA |
| CETP (rs3764261) | |||||
| TT | 8(5.1%) | 2(2.6%) | |||
| TG | 46(29.3%) | 24(31.2%) | |||
| GG | 103(65.6%) | 51(66.2%) | |||
| T allele frequency | 18.7% | 20.5% | 0.69 | NA | NA |
| ADAMTS9 (rs6795735) | |||||
| CC | 0 | 4(5.2%) | |||
| CT | 39(24.8%) | 16(20.8%) | |||
| TT | 118(75.2%) | 57(74.0%) | |||
| C allele frequency | 10.8% | 15.9% | 0.35 | NA | NA |
(※)adjusting for gender, baseline BCVA, AMD subtype.
(※※) adjusting for age, gender, baseline BCVA, AMD subtype.