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Stabilized helices and nonnatural helix mimetics: Several strategies that stabilize the α-helical conformation in peptides or mimic this domain with nonnatural scaffolds have been described. The most advanced efforts include β-peptide helices, terphenyl helix mimetics, miniproteins, peptoid helices, and side-chain cross-linked α-helices. This Account reviews our efforts to develop the hydrogen bond surrogate (HBS) derived α-helices. Green circles represent amino acid side chains.
