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. Author manuscript; available in PMC: 2020 Apr 29.
Published in final edited form as: Acc Chem Res. 2008 Jul 17;41(10):1289–1300. doi: 10.1021/ar700264k

FIGURE 3.

FIGURE 3.

Nucleation of short α-helices by replacement of an N-terminal i and i + 4 hydrogen bond (C=O ⋯ H–N) with a covalent link (C=X–Y–N). The hydrogen bond surrogate-based (HBS) α-helices contain a carbon-carbon bond derived from a ring-closing metathesis reaction.