Table 1.
Kinase profiles of current JAK2 inhibitors
| Kinase | Enzyme IC50, nM | |||
|---|---|---|---|---|
| Fedratinib | Ruxolitinib | Pacritinib | Momelotinib | |
| JAK1 | 105 | 3.3 | 1280 | 11 |
| JAK2 | 3 | 2.8 | 23 | 18 |
| JAK3 | 1002 | 428 | 520 | 155 |
| TYK2 | 405 | 19 | 50 | 17 |
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