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. 2020 Apr 20;4(8):1594–1605. doi: 10.1182/bloodadvances.2019001248

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Figure 1. — IL-2 affords additional prolongation of the half-life of adoptively transferred Tregs compared with rapa alone. (A) Experimental schema. (B) Longitudinal frequency of CFSE⁺ Tregs expressed as a percentage of the 1-hour postinfusion measurement. Tregs were defined as CD3⁺, CD4⁺, CD2⁺, and FOXP3⁺. *P < .05, percentage of CFSE⁺ Tregs IL-2+rapa vs rapa using repeated-measures analysis of variance (ANOVA). (C) Percentage of all CFSE⁺ cells that are positive for both CD25 and FOXP3 (left), CD25 only (middle), and negative for CD127 (right). *P < .05, IL-2+rapa vs rapa using repeated-measures ANOVA. NS, not significant.