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PK of itacitinib on day 1 and day 7 stratified by concomitant CYP3A4 inhibitor use in relation to the concentration needed to inhibit IL-6- or TPO-induced STAT phosphorylation by 50%. Data are shown as mean ± standard error of the mean. *Only 6 patient samples were available for analysis at the first time point (baseline). IC50, half maximal inhibitory concentration; TPO, thrombopoietin.
