| BSEP pIC50 |
Bile Salt Export Pump |
hepatic |
membrane vesicles |
|
187 |
| ADRA1B pIC50 |
adrenergic a1B pIC50 |
CNS |
intracell Ca |
|
3537 |
| ADRA2C pIC50 |
a2C adrenoceptor |
CNS |
CHO K1 |
|
2873 |
| ADRB2 pEC50 |
2 adrenoceptor |
CNS |
FRET |
|
2815 |
| CHRM1 pEC50 |
cholinergic receptor muscarinic 1 |
CNS |
CHO |
intracellular Ca fluorescence |
5315 |
| CHRM1 pIC50 |
cholinergic receptor muscarinic 1 |
CNS |
CHO |
intracellular
Ca fluorescence |
4547 |
| CHRM2 pEC50 |
cholinergic receptor muscarinic 2 |
CNS |
CHO |
intracellular Ca fluorescence |
4742 |
| DRD2 pEC50 |
dopamine D2 |
CNS |
HEK293F low Na GTPgS |
SPA |
14450 |
| GRIN1 pIC50 |
GRIN1 GRIN2B NR2B NR1A 2B
subunit pIC50 |
CNS |
|
|
2663 |
| HRH1 pIC50 |
histamine receptor H1 |
CNS |
|
luminescence |
7971 |
| HTR1B pIC50 |
5-hydroxytryptamine receptor 1B |
CNS |
10 μL LEADseeker
GTPgS |
|
6300 |
| HTR2A pEC50 |
5-hydroxytryptamine receptor 2A |
CNS |
HEK |
luminescence |
4259 |
| HTR2A pIC50 |
5-hydroxytryptamine receptor 2A |
CNS |
HEK |
luminescence |
4250 |
| HTR2C pEC50 |
5-hydroxytryptamine receptor 2C |
CNS |
CHO |
luminescence |
2938 |
| HTR2C pIC50 |
5-hydroxytryptamine receptor 2C |
CNS |
CHO |
luminescence |
2939 |
| HTR3A pIC50 |
5-hydroxytryptamine receptor 3A |
CNS |
FLIPR |
|
6645 |
| KCNA5 (Kv1.5) pIC50 |
KCNA5 (Kv1.5) |
cardiovascular |
CHO |
electrophys |
4178 |
| KCNE1 KCNQ1 (Kv7.1) pIC50 |
KCNE1 KCNQ1 (Kv7.1) |
Cardiovascular |
MinK human blocker CHO |
electrophys |
2373 |
| MAOA pIC50 |
monoamine oxidase A |
CNS |
|
FLINT |
344 |
| PDE3A pIC50 |
phosphodiesterase
3A |
Cardiac |
|
SPA (cAMP inhibition) |
614 |
| PDE4B pIC50 |
phosphodiesterase 4B |
CNS |
|
SPA |
564 |
| Phospholipidosid pEC50 |
phospholipidosis induction |
cellular tox |
HEPG2 |
FLINT |
278 |
| PI3K pIC50 |
phosphoinositide 3-kinase (pI3K) |
cellular tox |
|
TR FRET |
9173 |
| COX 2 pIC50 |
cyclooxygenase 2 |
cardiovascular |
|
FLINT SAR |
3865 |
| SCN5A (NaV1.5) pIC50 |
SCN5A (NaV1.5) |
cardiovascular |
|
|
3577 |
| SCL6A2 pIC50 |
noradrenaline Transporter NET |
CNS |
|
BacMam bind SPA |
2805 |
| SLC6A4 pIC50 |
seratonin Transporter
(SERT) |
CNS |
|
BacMam binding SPA |
3520 |
| OATP1B1 pIC50 |
organic anion transport
polypeptide (SLCO1B1) |
hepatic |
HEK |
image |
1789 |
