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. Author manuscript; available in PMC: 2020 Apr 29.
Published in final edited form as: Nat Protoc. 2019 Jul 24;14(8):2571–2594. doi: 10.1038/s41596-019-0195-x

Table 1 |.

Scheme for pipetting from four 96-well plates to one 384-well plate.

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
A A B A B A B A B A B A B A B A B A B A B A B A B
B C D C D C D C D C D C D C D C D C D C D C D C D
C A B A B A B A B A B A B A B A B A B A B A B A B
D C D C D C D C D C D C D C D C D C D C D C D C D
E A B A B A B A B A B A B A B A B A B A B A B A B
F C D C D C D C D C D C D C D C D C D C D C D C D
G A B A B A B A B A B A B A B A B A B A B A B A B
H C D C D C D C D C D C D C D C D C D C D C D C D
I A B A B A B A B A B A B A B A B A B A B A B A B
J C D C D C D C D C D C D C D C D C D C D C D C D
K A B A B A B A B A B A B A B A B A B A B A B A B
L C D C D C D C D C D C D C D C D C D C D C D C D
M A B A B A B A B A B A B A B A B A B A B A B A B
N C D C D C D C D C D C D C D C D C D C D C D C D
O A B A B A B A B A B A B A B A B A B A B A B A B
P C D C D C D C D C D C D C D C D C D C D C D C D

The numbers in the first row and the letters in the leftmost column indicate the coordinates of a 384-well plate. The remaining letters A, B, C, and D refer to four 96-well plates. Using an 8-channel pipette, primers in each column of 96-well plate A are pipetted to a column with wells marked A in this diagram of a 384-well plate. This requires 12 transfers. The process is repeated for 96-well plates B, C, and D. The overall operation requires 48 transfers, with 8 wells being pipetted per transfer.