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. 2020 Apr 28;11:2052. doi: 10.1038/s41467-020-15887-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Transcriptome-wide mRNA sequencing (a) and targeted RNA sequencing (b) of HEK293T cells expressing next-generation CBEs. Base editing efficiencies were reported for the most edited base in the target sites. Values in b reflect the mean of n = 2 independent biological replicates. c correlation of the numbers of C-to-U mutations observed in transcriptome-wide mRNA sequencing with percentage of C-to-U conversion in targeted RNA sequencing. Values for x-axis reflect the mean editing efficiency at sites shown in b from n = 2 independent biological replicates. Values for y-axis reflect the mean of n = 3 biological replicates shown in a. All data presented are provided as Source Data.