Fig. 5. Next-generation CBEs showed higher DNA on-target editing efficiencies than SECURE-CBEs and BE4-YE1.

C-to-T editing efficiencies of next-generation CBEs, SECURE-BE4s, and BE4-YE1 at 33 genomic sites (site 1–22 and 24–34) (a) and 6 previously published sites (b). Base editing efficiencies are reported for the base within the target site with the highest editing frequency. Next-generation CBEs reported here are in blue, BE4 (containing rAPOBEC1)⁵ is in black, BE4-YE¹⁹ is in pink, and SECURE-CBEs⁹ are in orange. The red horizontal line across each plot represent the mean of n = 3 independent biological replicates, expect for conditions with data points not included due to insufficient reads (<5000). All data presented are provided as Source Data.