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Inclusion of PGSs from comorbid traits improved the performance of prediction models. Shown in the figure were receiver operating characteristics (ROC) curves from the schizophrenia sPGS calculated at P-value of 1e-3 alone and the schizophrenia sPGS plus sPGSs from other comorbid traits. Also shown were ROC curves from independent CATIE dataset. In both the MGS+SSCCS and CATIE datasets, the inclusion of sPGSs from comorbid traits improved the performance of the prediction models.
