Table 1.
LASSO regression selected sPGSs
| Estimate | Std.Err | Z.Value | Pr(>|Z|) | In.Model | |
|---|---|---|---|---|---|
| BIP_1e-2 | 573.23 | 54.88 | 10.45 | < 2.00E-16 | Y |
| CAD_1e-2 | −374.85 | 101.04 | −3.71 | 0.0002 | Y |
| CD_1e-2 | −606.36 | 105.09 | −5.77 | 7.94E-09 | Y |
| MDD_1e-2 | −444.17 | 48.72 | −9.12 | < 2.00E-16 | Y |
| BIP.II_1e-2 | 527.50 | 93.76 | 5.63 | 1.84E-08 | Y |
| OPPH_1e-2 | −2863.28 | 841.99 | −3.40 | 0.0007 | Y |
| SCZ_1e-2 | 11468.94 | 277.31 | 41.36 | 2.00E-16 | Y |
| UC_1e-2 | −485.90 | 108.81 | −4.47 | 7.98E-06 | Y |
| BMI_1e-3 | −244.17 | 85.33 | −2.86 | 0.0042 | Y |
| evrSmk_1e-3 | 86.32 | 26.78 | 3.22 | 0.0013 | Y |
| MDD_1e-3 | −28.64 | 17.49 | −1.64 | 0.1015 | Y |
| BIP.II_1e-3 | −155.38 | 34.19 | −4.55 | 5.49E-06 | N |
| SCZ_1e-3 | 1845.42 | 127.91 | 14.43 | < 2.00E-16 | Y |
| ASD_1e-4 | 22.30 | 6.44 | 3.46 | 0.0005 | Y |
| BIP_1e-4 | 11.84 | 6.84 | 1.73 | 0.0835 | Y |
| DS_1e-4 | −445.73 | 63.21 | −7.05 | 1.77E-12 | Y |
| YoS_1e-4 | 598.37 | 162.80 | 3.68 | 0.0002 | Y |
| earlyLate_1e-5 | 15.78 | 7.80 | 2.02 | 0.0430 | Y |
| evrSmk_1e-5 | −16.29 | 5.57 | −2.93 | 0.0034 | N |
| NEU_1e-5 | 169.77 | 28.52 | 5.95 | 2.65E-09 | Y |
| SCZ_1e-5 | −292.10 | 22.91 | −12.75 | < 2.00E-16 | N |
| SWB 1e-5 | 74.75 | 23.54 | 3.18 | 0.0015 | Y |
Abbreviations: BIP, bipolar disorder; CAD, coronary artery disease; CD, Crohn s disease; MDD, major depressive disorder; BIP.II, bipolar disorder, GWAS II; OPPH, one person income per household; SCZ, schizophrenia; UC, ulcerative colitis; BMI, body mass index; evrSmk, ever smoker; ASD, autism spectrum disorder; DS, depressive symptoms; YoS, years of schooling; earlyLate, early person vs late person; NEU, neuroticism; SWB, subjective wellbeing. The suffix after the abbreviation indicated the P-value threshold used to calculate the PGS.