Table 4.
Presence of antibiotic resistance genes (ARGs) at time points during the first year of life
| Number of subjects# | % of subjects with ARG present at time points | Number of subjects* | % of subjects with ARG present at time points | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Antibiotic resistance genotype | ARG | W3 | W3 and M12 | W3 and M12 | W3 | W3 to M3 | W3 to M6 | W3 to M12 | W3 to M3 | W3 to M6 | W3 to M12 |
| Fosfomycin | fosA | 21 | 11 | 52% | 8 | 7 | 6 | 4 | 88% | 75% | 50% |
| Beta-lactam | blaZ | 21 | 2 | 10% | 7 | 1 | 1 | 0 | 14% | 14% | 0% |
| Aminoglycoside | aac(6′)-aph(2″) | 11 | 5 | 45% | 5 | 1 | 0 | 0 | 20% | 0% | 0% |
| Macrolide | lsa(A) | 13 | 2 | 15% | 5 | 5 | 3 | 1 | 100% | 60% | 20% |
| Quinolone | oqxB | 14 | 4 | 29% | 5 | 4 | 1 | 1 | 80% | 20% | 20% |
| Macrolide | erm(B) | 13 | 11 | 85% | 4 | 2 | 2 | 2 | 50% | 50% | 50% |
| Macrolide | erm(X) | 6 | 5 | 83% | 4 | 3 | 2 | 1 | 75% | 50% | 25% |
| Macrolide | mef(A) | 15 | 15 | 100% | 4 | 4 | 3 | 3 | 100% | 75% | 75% |
| Macrolide, Lincosamide and Streptogramin B | msr(D) | 14 | 14 | 100% | 4 | 4 | 2 | 2 | 100% | 50% | 50% |
| Tetracycline | tet(M) | 15 | 11 | 73% | 4 | 2 | 1 | 1 | 50% | 25% | 25% |
| Aminoglycoside | aph(3′)-III | 7 | 5 | 71% | 3 | 2 | 1 | 1 | 67% | 33% | 33% |
| Sulphonamide | sul2 | 8 | 4 | 50% | 3 | 3 | 2 | 2 | 100% | 67% | 67% |
| Tetracycline | tet(O) | 6 | 4 | 67% | 3 | 3 | 3 | 2 | 100% | 100% | 67% |
| Tetracycline | tet(Q) | 5 | 4 | 80% | 3 | 3 | 3 | 3 | 100% | 100% | 100% |
| Tetracycline | tet(W) | 11 | 10 | 91% | 3 | 3 | 3 | 3 | 100% | 100% | 100% |
| Beta-lactam | blaTEM-1b | 9 | 6 | 67% | 2 | 2 | 2 | 1 | 100% | 100% | 50% |
| Aminoglycoside | aadE | 1 | 1 | 100% | 1 | 1 | 0 | 0 | 100% | 0% | 0% |
# subjects with stool samples at both week 3 and month 12 (N = 22). *subjects with stool samples at all timepoints (N = 8)