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. 2020 Apr 28;20:359. doi: 10.1186/s12885-020-06868-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Macrophage phenotypes transition over the course of trastuzumab treatment. a Representative flow cytometry graphs of Day 0 control tumors and Day 4 and Day 7 trastuzumab treated tumors (96 and 24 h after treatment). Visual increases are observed in CD38+/CD206+ co-expressing macrophages on Day 4, 24 h after treatment and CD38+/CD206- M1 macrophages on Day 7, 24 h after trastuzumab treatment. b Percent of macrophages co-expressing CD38 and CD206 is shown revealing a significant increase (P = 0.02) from control in Day 4 treated tumors, after two doses of trastuzumab. c Percent of macrophages with an M1 phenotype (CD38+/CD206-) is shown revealing a significant increase (P = 0.02) in the M1 macrophage population in treated Day 7 tumors after three doses of trastuzumab. d Percent of macrophages with a non-differentiated, M0 phenotype (CD38−/CD206-) is shown revealing a significant decrease in population observed on Day 4 (P = 0.02) and Day 7 (P = 0.03), 24 h after treatment. e Percent of M2 macrophages (CD38−/CD206+) (no significant differences were observed between control and treated tumors)