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. 2020 Apr 28;20:359. doi: 10.1186/s12885-020-06868-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Vascular changes over the course of trastuzumab treatment positively correlate with macrophage phenotypic alterations. a Representative images of CD31 (top) and α-SMA (bottom) in Day 4 control and trastuzumab treated tumors. b CD31 microvessel density and c α-SMA coverage in control and trastuzumab treated tumors (no significant differences were observed). d Vessel maturation index as determine by ratio of α-SMA to CD31 microvessel density in control and trastuzumab treated tumors is shown, revealing a significant increase in vessel maturation index on Day 7, 24 h after a third dose of trastuzumab (P = 0.04). e Linear correlation between vessel maturation index and percent M1 macrophages in corresponding tumor halves as determined by flow cytometry showing a positive linear correlation (R = 033, P = 0.04)