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. 2020 Apr 21;7(2):ENEURO.0245-19.2020. doi: 10.1523/ENEURO.0245-19.2020

Figure 2.

Figure 2.

Validation of the SA task in mice. A, Number of training sessions until reaching criteria (in Mag and nose-poke training; stages 1 and 2). Stage 2 consisted of two parts: nose-poke training with 30 trials (NP 30) and nose-poke training with 50 trials (NP 50). B, Magazine entries of C57BL/6-SA mice declined across SA sessions (stage 3), demonstrating effective ‘attenuation’ of the feedback signal (i.e., attenuation of the association strength between signal and reward). C, In the final extinction test (stage 4), C57BL/6-SA mice (n = 12) showed significantly more UCTs in comparison with C57BL/6-RE mice (i.e., mice that underwent only RE in stage 4 without prior SA; n = 12). D, The mean number of UCT was significantly higher in SA mice in four out of five trial blocks. E, All animals increased the number of ENPs in the final extinction test. However, ENP of C57BL/6-SA mice were significantly higher compared with C57BL/6-RE mice in the final extinction test (stage 4). F, Examination of ENP in UCT showed increased compulsivity in C57BL/6-SA compared with C57BL/6-RE, demonstrating successful implementation of the SA task in mice. Mag, food magazine; NP, nose poke. Data are expressed as mean ± SEM. *p < 0.05.