Figure 8. Timeline of the cellular events during GGA-induced cell death of human hepatoma HuH-7 cells.
GGA-induced cellular events described in the present study are arranged in a sequence of time when each event was detected in HuH-7 cells after addition of GGA to the culture medium, which does not necessarily mean to infer a causal relationship between events. Priming of the NLRP3 inflammasome means up-regulation of the mRNA levels of NLRP3 and IL1B genes.