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. 2020 Apr 28;20:102. doi: 10.1186/s12866-020-01785-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Drug non-susceptibility in Haemophilus influenzae. a Incidences of drug non-susceptibility to different antimicrobial agents in H. influenzae isolates from 2007 to 2018 (n = 2091) are shown. Fisher’s exact tests or Pearson Chi-square tests were used to assess the significance of the non-susceptible rate of each drug in each year when compared to the overall mean value. *P < 0.05, **P < 0.01, ***P < 0.001. x̄, mean value. b Comparisons of drug non-susceptibility rates in β-lactamase-positive and β-lactamase-negative H. influenzae isolates. P-values are obtained from Fisher’s exact tests