Maximal change in tumor burden from baseline is shown. Changes in tumor burden are presented at the patient level (A) and at the lesion level (injected lesions in panel B and uninjected lesions in panel C). CR, complete response; irRC, immune-related response criteria; PD, progressive disease; PR, partial response; SD, stable disease. *Patient had a 99.8% reduction in tumor burden. †Patients had a confirmed complete response. ‡Patients had 100% reduction in tumor burden, but response was unconfirmed.