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Changes in subsets of T-cells according to confirmed best response. (A) Changes in activated CD8+ T-cell count after administration of talimogene laherparepvec and talimogene laherparepvec + ipilimumab. (B) Changes in ICOS+ CD4+ T-cell count after administration of talimogene laherparepvec and talimogene laherparepvec + ipilimumab. CR, complete response; PD, progressive disease; PR, partial response; SD, stable disease.
