Table 4.

ROBINS-I risk of bias assessment

Study	Confounding	Selection of participants into study	Classification of intervention	Deviation from intended intervention	Missing data	Measurement of outcomes	Selection of the reported results	Over all
Nayar et al. [15]	Serious risk	Low risk	Low risk	Low risk	Low risk	Low risk	Moderate risk	Serious risk
Verrone et al. [14]	Serious risk	Low risk	Low risk	Low risk	Low risk	Moderate risk	Moderate risk	Serious risk