Table 2.

EV-miRNAs in the first quartile of expression that are involved in macrophage M1 or M2 phenotype

	% weight EVs/iEVs	Down IFNγ	Up IFNγ	Only EVs	Only iEVs	M1 promoting	M1 suppressing	M2 promoting	M2 suppressing
M1 phenotype
miR-29b-3p	0.07/0.27		X			X
miR-145-5p	1.84/0.79	X				X
miR-27a-3p	0.90/0.33	X				X			X
miR-27b-3p	0.32/0.18	X				X			X
miR-130a-3p	0.57/0.78					X			X
miR-26a-5p	0.64/1.06								X
miR-26b-5p	0.15/0.20								X
M2 phenotype
miR-24-3p	19.63/18.47						X	X
miR-146b-5p	0.04/0.51		X				X	X
miR-181a-5p	0.11/0.18						X	X
miR-34a-5p	0.70/0.93							X
miR-222-3p	5.74/7.61							X