Table 3.

pH, gut histology and immunohistochemistry parameters at different intestinal levels

	Butyrate		Placebo		P - value
	Mean	SD	Mean	SD	Treatment	Period	Age	Sex	Treatment x Period
pH
D	5.96	0.90	6.39	0.28	0.119	0.308	0.36	0.149	0.053
J	7.20	0.52	7.46	0.21	0.166	0.442	0.385	0.803	0.225
I	7.58	0.22	7.49	0.25	0.110	0.143	0.66	0.418	0.061
CAE	6.74	0.15	6.67	0.14	0.820	0.047	0.746	0.961	0.768
LVC	6.61	0.20	6.64	0.24	0.697	0.001	0.174	0.966	0.467
RDC	6.56	0.24	6.55	0.10	0.375	0.165	0.142	0.852	0.583
Crypt depth (μm)
CAE	262	33	262	34	0.143	0.195	0.822	0.916	0.118
LVC	318	42	320	41	0.262	0.662	0.731	0.488	0.251
RDC	399	94	518	84	< 0.001	0.314	0.798	< 0.001	0.002
Area % of CD3 positive cells
D	10.096	5.131	6.193	4.535	0.745	0.010	0.802	0.127	0.192
J	8.306	6.108	12.367	7.903	0.241	0.051	0.253	0.503	0.282
I	9.964	6.782	14.451	10.616	0.258	0.036	0.313	0.733	0.283
CAE	16.562	10.081	16.945	9.767	0.482	0.151	0.924	0.682	0.433
LVC	11.585	8.596	12.441	4.212	0.301	0.407	0.293	0.598	0.407
RDC	11.126	7.560	14.240	6.977	0.207	0.173	0.398	0.769	0.254
Area % of CD20 positive cells
D	6.571	7.349	5.519	4.850	0.232	0.004	0.235	0.076	0.085
J	3.798	4.169	2.279	1.585	0.241	0.051	0.253	0.503	0.282
I	9.428	11.087	3.143	2.409	0.714	0.529	0.761	0.021	0.840
CAE	2.427	2.981	2.720	2.110	0.759	0.159	0.505	0.079	0.704
LVC	3.186	3.127	2.452	2.854	0.153	0.068	0.008	0.032	0.034
RDC	2.950	3.022	3.240	2.448	0.940	0.324	0.510	0.785	0.805
Number of KI67 positive cells per crypt
RDC	25	10	32	12	0.650	0.984	0.687	0.632	0.972

D duodenum, J jejunum, I ileum, CAE cecum, LVC left ventral colon, RDC right dorsal colon