Table 1.
Effect of PFT on cell cycle and apoptotic regulators in tumor tissues of the different groups as determined by flow cytometry
| Groups | Inocul Control | PFT (pre-inocul) | PFT (post-inocul) |
|---|---|---|---|
| Parameter | |||
| P53 expression | 17.55±0.95 | 63.46± 6.72* | 42.05± 6.68*† |
| % change from inocul control | - | +261% | +139% |
| P21 expression | 12.03± 0.92 | 55.29± 1.68* | 39.60± 4.71*‡ |
| % change from inocul control | - | +359% | +229% |
| P27 expression | 23.11± 1.61 | 60.46± 1.52* | 35.96± 1.37*‡ |
| % change from inocul control | - | +161% | +55% |
| Bax expression | 12.15± 0.62 | 52.66± 3.16* | 30.62± 1.34*‡ |
| % change from inocul control | - | +333% | +152% |
| Bcl2 expression | 66.89±2.34 | 36.47±0.89* | 47.15±1.68*‡ |
| % change from inocul control | - | -45% | -29% |
| Bax/Bcl2 ratio | 0.17±0.008 | 1.43±0.075* | 0.64±0.038*‡ |
| % change from inocul control | - | +741% | +276% |
| Caspase-3 expression | 20.98±1.63 | 46.89±2.32* | 39.67±0.66*† |
| % change from inocul control | - | 123.50% | 89.00% |
| MMP | 71.14±3.27 | 15.86±3.69* | 43.06±3.65*† |
| % change from inocul control | - | -77.7% | -39.5% |
Each value represents the mean±SE of 6 mice/group. *P ≤ 0.01 vs. inocul control group; †P < 0.05 vs. pre-inocul group; ‡P < 0.01 vs. pre-inocul group