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. 2020 Apr 28;17:136. doi: 10.1186/s12974-020-01803-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Spectral domain optical coherence tomography (SD-OCT) images of the anterior segment from wild type mice and rTg4510 mice aged 11 months. aEn face view of the WT mouse eye (3 mm × 3 mm rectangular scan) and b corresponding SD-OCT scan of the anterior segment. Red arrowed line represents the en face location of the scan. c, f Structure of the corneal epithelium and stroma, as shown using SD-OCT. No visible differences in the corneal structure or anterior segment were observed between WT (a-c) and rTg4510 mice (d-f). g, h There were no quantitative differences in corneal epithelial (g) or stromal thickness (h) between WT and rTg4510 mice. Data are shown as mean ± SEM where NS represents a comparison that is not statistically significant (n = 8 per group) as assessed using unpaired Student's t-test. Scale bars represent 200 μm in Fig. 1a and d, and 100 μm (vertical axis), and 200 μm (horizontal axis) in Fig. 1b and e