FIGURE 5.

Characterization of proteins loaded in Exo^Normoxic and Exo^Hypoxic by mass spectrometry. Proteomic profiling of Exo^Normoxic and Exo^Hypoxic was performed by LC/MS/MS and data analyzed by IPA software. A, Cellular localization of proteins loaded in Exo^Normoxic and Exo^Hypoxic are presented in pi diagrams. B, Top five canonical pathways in Exo^Normoxic and Exo^Hypoxic are shown. In each case, percentage overlap with the dataset (left panel) as well as –log (P value; right panel) are presented. Exo^Hypoxic, exosomes secreted under hypoxic condition; Exo^Normoxic, Exosomes secreted under normoxic condition; IPA, ingenuity pathway analysis; LC/MS/MS, liquid chromatography/mass spectrometry [Color figure can be viewed at wileyonlinelibrary.com]