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. Author manuscript; available in PMC: 2021 Apr 7.
Published in final edited form as: Biochemistry. 2020 Mar 26;59(13):1299–1308. doi: 10.1021/acs.biochem.0c00132

Figure 4. eIF2α binding in the productive and nonproductive eIF2B•eIF2 complexes.

Figure 4.

eIF2B is in a similar orientation to that in Figure 2. The coloring is as in Figure 2, but with more aggressive shading, to zoom in on the eIF2α interface. More distant portions of the complex are invisible due to shading or are cut out. eIF2α-NTD from the nonproductive eIF2B•eIF2(α-P) complex (left) and from the productive eIF2B•eIF2 complex (right)2 are shown as gold ribbon. The rest of eIF2 is not shown. Residues in eIF2B subunits corresponding to sites of Gcd− mutations in S. cerevisiae are colored black; residues corresponding to sites of Gcn− mutations in S. cerevisiae are colored red; Q130 in human eIF2Bβ, corresponding to the site of a lethal mutation in S. cerevisiae is colored magenta. Residues discussed in the text are labeled. The residues in human eIF2α, corresponding to the sites of the Y81S and R88T Gcn− mutations in S. cerevisiae eIF2α, are shown as orange sticks (not labeled).