Table 1.

Maximum Credible Allele Frequency (MCAF): Allelic Contribution, Penetrance, MAF cutoff, pathogenic variants in ClinVar from Trusted submitters and final MAF cutoff.

Prevalence	Max. Allelic Contribution	Penetrance	MCAF (Whiffin et al. [22])	Max. MAF in ClinVar	Final Cut Off
0.000025	0.05	1	0.00025	0.00358	0.00025