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. Author manuscript; available in PMC: 2020 Apr 29.
Published in final edited form as: Biomark J. 2019 Apr 26;5(1):4. doi: 10.36648/2472-1646.5.1.59

Figure 1.

Figure 1

c-FLIP variants as anti-apoptotic proteins control apoptosis and pathways. Binding of TRAIL with its receptors DR4 and DR5 or interaction of Fas ligand (CD95L) to Fas receptor (CD95) triggers the death receptor (extrinsic) and subsequently mitochondrial apoptosis signaling (intrinsic) pathways through FADD-dependent autocatalytic activation of caspases-8 and -10 and Bid cleavage to truncated Bid. c-FLIPL and c-FLIPS isoforms suppress caspase-8 and -10 activation, therefore preventing the downstream apoptosis cascade (Modified from Safa [1]).