Table I.
Clinical characteristics of patients with COVID-19 in intensive care unit
| Clinical feature | IFN-negative (n = 5) | IFN-positive (n = 21) | P value |
|---|---|---|---|
| Age (y), median (min-max) | 81 (63-83) | 74 (28-91) | .696 |
| Sex (male), n (%) | 5 (100) | 18 (86) | 1.000 |
| Delay between symptom onset and ICU admission (d) | 7 (1-11) | 7 (0-15) | .769 |
| Bacterial coinfection during ICU stay, n (%) | 3 (60) | 7 (33) | .3402 |
| Diabetes, n (%) | 1 (20) | 3 (14) | .5043 |
| Chronic obstructive pulmonary disease, n (%) | 0 (0) | 3 (14) | 1.000 |
| Cardiovascular disease, n (%) | 2 (40) | 9 (43) | 1.000 |
| Hypertension, n (%) | 3 (60) | 7 (33) | .3402 |
| Cancer, n (%) | 1 (20) | 3 (14) | 1.000 |
| Active smokers, n (%) | 0 (0) | 1(5) | 1.000 |
| BMI >30 kg/m2, n (%) | 3 (60) | 8 (38) | .620 |
| Biological feature, median (min-max) | |||
| Viral load at diagnosis (Ct), median (min-max) | 20.9 (18-28.2) | 25.1 (16.1-38.0) | .172 |
| Outcome, n (%) | |||
| Standard oxygen therapy only | 0 (0) | 5 (24) | .5451 |
| High flow oxygen therapy only | 0 (0) | 7 (33) | .278 |
| Invasive ventilation at any time during ICU stay | 5 (100) | 9 (42) | .0425 |
| ICU length of stay, median (min-max) | 20 (7-30) | 5 (0-35) | .0503 |
| Mortality at day 28 after symptom onset, n (%) | 2 (40) | 8 (38) | 1.000 |
P values were calculated using Mann-Whitney test for quantitative values and using Fisher-exact test for qualitative ones.
Statistical significance is defined by P < .05 (boldface).
BMI, Body mass index; ICU, intensive care unit.