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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Ann N Y Acad Sci. 2019 Sep 16;1456(1):44–63. doi: 10.1111/nyas.14233

Figure 4. Apomorphine hydrochloride suppresses gpr126 hypomorphic phenotype at high doses.

Figure 4.

(A-C, G-J) Whole-mount in situ hybridization for mbp in PLLn of gpr126st63 (A-C) or gpr126stl215 (G-J) with control, apomorphine, or forskolin (FSK) treatment at 5 dpf. Black arrows indicate PLLn. (D, K) Quantification expressed as a percentage of larvae with each mbp PLLn phenotype at 5 dpf. * p<0.05, *** p<0.001, Fisher’s Exact Test, “wild-type” vs. “mutant” (gpr126st63 or gpr126stl215) categories for treated vs. control. (E-F) Survival curve following 24-hour treatment with indicated concentrations of apomorphine. Dots indicate mean ± SD % alive across technical replicates. *** p<0.001, 0 vs.100 μM apomorphine. Sample numbers in Detailed Methods.