Figure 1.

Label‐free proteomics of TA muscle from adult and old mice. (a) Heatmap of significantly changed proteins (fold change >2, −10logP > 20 equivalent to p‐value < .01) between adult (adult: 6 months old, n = 6), adult exercised (adult Ex, n = 5), old (old: 24 months old, n = 5), and old exercised (old Ex, n = 4). (b, c) Pathway analysis of quantitative proteomic data reveals a downregulation of proteins involved in mitochondrial electron transport chain and an upregulation of proteins involved in muscle contraction during aging