Nutraceutical/Botanical	Significant Concern	Theoretical/Minor Concern
Vitamin D		Steroids, phenobarbital and dilantin can interfere with vitamin D metabolism Orlistat and cholestyramine may interfere with vitamin D absorption
Vitamin A	Warfarin activity may be affected by Vitamin A	Retinoid medications and other products containing vitamin A may interact with each other Neomycin, orlistat, and cholestyramine may interfere with vitamin A absorption
Vitamin C	Warfarin activity may be affected by Vitamin C	Vitamin C may increase aluminum absorption from antacids Vitamin C may decrease exogenous estrogen metabolism Vitamin C may decrease fluphenazine concentrations Large doses of vitamin C may reduce half-life of HIV protease inhibitors
Zinc		Zinc may decrease absorption of some antibiotics when taken at same time Zinc may increase side effects of cisplatin Zinc may decrease the absorption of penicillamine Amiloride may increase amount of zinc in body
Melatonin		Possible interactions with warfarin, nifedipine and immune suppressing drugs.
Quercetin	Quercetin may affect medications metabolized by CYP2C8, CYP2D6, CYP3A4, and P-glycoprotein substrates	Quercetin may decrease the effectiveness of some antibiotics Quercetin may increase concentrations of cyclosporine
Fish Oil		Fish oil may slow blood clotting, taking with other blood thinners may increase chances for bruising and bleeding
N-Acetyl Cysteine		Caution in those with a sulfur sensitivity
Glutathione		Caution in those with a sulfur sensitivity
Astragalus		Astragalus may decrease the effectiveness of cyclophosphamide and other immune suppressants Astragalus may decrease the excretion of lithium
Andrographis		Andrographis may decrease blood pressure, taking with blood pressure medications may cause hypotension Andrographis may decrease the effectiveness of immune suppressing medications Andrographis may slow blood clotting, taking with other blood thinners may increase chances for bruising and bleeding
Reishi		Reishi may decrease blood pressure, taking with blood pressure medications may cause hypotension High doses of reishi may slow blood clotting, taking with other blood thinners may increase chances for bruising and bleeding
Berberine	Berberine may decrease metabolism of cyclosportine	Berberine may affect medications metabolized by CYP3A4
Baicalin		Baicalin may decrease the effects of exogenous estrogen Baicalin may decrease the excretion of lithium
Echinacea		Echinacea might decrease caffeine metabolism Echinacea may affect medications metabolized by CYP3A4 and CYP1A2 Echinacea may decrease the effectiveness of immune suppressing medications
Goldenseal		Goldenseal may decrease cyclosporine metabolism Goldenseal may increase digoxin levels Goldenseal may affect medications metabolized by CYP2D6, CYP3A4, and P-Glycoprotein substrates.
Curcurmin		Curcumin may slow blood clotting, taking with other blood thinners may increase chances for bruising and bleeding
Bromelain		Bromelain might increase levels of amoxicillin Bromelain may change levels of tetracyclines Bromelain may slow blood clotting, taking with other blood thinners may increase chances for bruising and bleeding.
Resveratrol		Resveratrol may affect medications metabolized by CYP3A4. Resveratrol may slow blood clotting, taking with other blood thinners may increase chances for bruising and bleeding.
Sulforaphane		Sulforaphane may affect medications metabolized by CYP1A2
Boswellia		None known