Table 2.
Hazard ratios (95% confidence interval) of cardiac conditions 20 years from diagnosis by treatment era*
| Diagnosis by decade | Hazard ratio (95% CI) | ||||
|---|---|---|---|---|---|
| Heart failure | Coronary artery disease | Valvular heart disease | Pericardial disease | Arrhythmia | |
| All survivors | |||||
| 1970-79 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| 1980-89 | 1.07 (0.78 to 1.45) | 0.65 (0.45 to 0.92) | 1.08 (0.63 to 1.85) | 0.57 (0.18 to 1.81) | 1.22 (0.69 to 2.17) |
| 1990-99 | 0.77 (0.53 to 1.14) | 0.53 (0.36 to 0.77) | 0.87 (0.33 to 2.33) | 0.80 (0.26 to 2.46) | 1.74 (0.99 to 3.03) |
| Leukemia: | |||||
| 1970-79 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| 1980-89 | 0.80 (0.39 to 1.66) | 0.69 (0.33 to 1.44) | 0.64 (0.51 to 0.80) | N/E | 0.64 (0.21 to 1.93) |
| 1990-99 | 1.05 (0.36 to 3.12) | 0.83 (0.31 to 2.22) | 3.97 (0.52 to 30.34) | N/E | 0.45 (0.11 to 1.85) |
| CNS tumors: | |||||
| 1970-79 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| 1980-89 | 0.58 (0.09 to 3.94) | 0.80 (0.19 to 3.43) | N/E | N/E | 1.47 (0.95 to 2.26) |
| 1990-99 | 1.31 (0.21 to 8.39) | 0.60 (0.12 to 2.88) | N/E | N/E | N/E |
| Hodgkin lymphoma: | |||||
| 1970-79 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| 1980-89 | 1.25 (0.66 to 2.35) | 0.77 (0.40 to 1.45) | 1.59 (0.83 to 3.06) | N/E | 1.24 (0.46 to 3.39) |
| 1990-99 | 0.77 (0.31 to 1.93) | 0.44 (0.23 to 0.85) | 0.41 (0.05 to 3.35) | N/E | 1.50 (0.44 to 5.08) |
| Non-Hodgkin lymphoma: | |||||
| 1970-79 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| 1980-89 | 0.98 (0.46 to 2.12) | 0.82 (0.25 to 2.75) | N/E | 0.27 (0.02 to 3.52) | 3.30 (0.41 to 26.60) |
| 1990-99 | 0.41 (0.14 to 1.23) | 0.86 (0.23 to 3.22) | N/E | 0.34 (0.06 to 2.0) | 3.08 (0.46 to 20.70) |
| Kidney tumor: | |||||
| 1970-79 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| 1980-89 | 1.16 (0.42 to 3.23) | N/E | 0.67 (0.09 to 5.03) | N/E | 1.12 (0.83 to 1.51) |
| 1990-99 | 0.35 (0.10 to 1.26) | 1.68 (0.11 to 24.71) | 0.49 (0.04 to 6.56) | N/E | N/E |
| Neuroblastoma: | |||||
| 1970-79 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| 1980-89 | 3.22 (0.83 to 12.53) | 0.64 (0.17 to 2.43) | N/E | N/E | N/E |
| 1990-99 | 5.72 (1.58 to 20.67) | 0.49 (0.05 to 4.46) | N/E | N/E | N/E |
| Soft tissue sarcoma: | |||||
| 1970-79 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| 1980-89 | 1.08 (0.30 to 3.85) | 0.47 (0.13 to 1.68) | N/A | 0.84 (0.05 to 15.44) | 0.82 (0.22 to 3.06) |
| 1990-99 | 0.59 (0.24 to 1.45) | N/E | N/A | N/E | N/E |
| Bone cancer: | |||||
| 1970-79 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| 1980-89 | 1.69 (0.97 to 2.97) | 0.92 (0.38 to 2.24) | N/E | N/E | 2.46 (0.46 to 13.12) |
| 1990-99 | 0.74 (0.26 to 2.09) | 0.53 (0.14 to 2.07) | N/E | N/E | 1.53 (0.26 to 9.15) |
CNS=central nervous system; N/E=not estimable owing to small cell size.
*
Adjusted for age at diagnosis, race, and sex.