Table 3.

Multivariable analysis of cardiac conditions by treatment era and cardiovascular risk factors 20 years from diagnosis

Risk factors by treatment era	Hazard ratio (95% CI)
	Heart failure	Coronary artery disease	Valvular heart disease	Pericardial disease	Arrhythmia
Sex:
Male	1.0
Female	1.51 (1.10 to 2.06)	0.87 (0.62 to 1.23)	1.25 (0.74 to 2.12)	0.68 (0.29 to 1.58)	1.25 (0.79 to 1.99)
Treatment era:
1970-79	1.0	1.0	1.0	1.0	1.0
1980-89	0.89 (0.67 to 1.17)	0.66 (0.42 to 1.02)	1.36 (0.77 to 2.43)	0.57 (0.16 to 1.97)	1.16 (0.65 to 2.05)
1990-99	0.70 (0.45 to 1.08)	0.63 (0.36 to 1.08)	1.33 (0.42 to 4.21)	0.96 (0.23 to 4.02)	1.71 (0.96 to 3.07)
Mean heart dose (Gy):
None	1.0	1.0	1.0	1.0	1.0
1-15	0.74 (0.54 to 1.03)	1.31 (0.88 to 1.96)	1.12 (0.33 to 3.79)	0.64 (0.19 to 2.20)	0.97 (0.54 to 1.73)
15.1-34.99	1.56 (1.05 to 2.33)	2.26 (1.32 to 3.84)	2.03 (0.64 to 6.44)	0.88 (0.21 to 3.64)	0.89 (0.37 to 2.18)
≥35	3.95 (2.87 to 5.43)	5.86 (3.69 to 9.28)	13.97 (6.01 to 32.48)	2.77 (0.59 to 12.88)	2.74 (1.10 to 6.81)
Anthracycline dose (mg/m2):
None	1.0	1.0	1.0	1.0	1.0
<250	2.76 (1.93 to 3.97)	1.42 (0.93 to 2.16)	1.67 (0.78 to 3.55)	1.38 (0.43 to 4.49)	1.38 (0.81 to 2.36)
≥250	9.29 (6.01 to 14.37)	1.77 (1.15 to 2.72)	2.04 (1.06 to 3.93)	2.81 (0.85 to 9.34)	3.81 (2.13 to 6.80)
Comorbidities:
Diabetes	2.66 (1.67 to 4.25)	1.55 (0.67 to 3.58)	0.79 (0.10 to 6.24)	2.58 (0.26 to 25.80)	2.51 (0.82 to 7.71)
Dyslipidemia	2.32 (1.53 to 3.52)	3.49 (2.11 to 5.77)	2.43 (0.65 to 9.02)	1.49 (0.27 to 8.25)	3.54 (1.80 to 6.96)
Hypertension	4.93 (3.61 to 6.72)	4.75 (3.37 to 6.69)	3.12 (1.09 to 8.91)	6.35 (1.56 to 25.83)	2.59 (1.27 to 5.30)

Estimates adjusted for all variables in the table: race, age at diagnosis, body mass index, smoking, and exercise intensity (metabolic hours/week).