Table 4.
Hazard ratios of cardiac conditions per five year treatment era
| Five year treatment era (continuous variable) | Hazard ratio (95% CI) | ||||
|---|---|---|---|---|---|
| Heart failure | Coronary artery disease | Valvular heart disease | Pericardial disease | Arrhythmia | |
| Adjusted for demographics and modifiable risk factors | 0.97 (0.88 to 1.06) | 0.80 (0.71 to 0.91) | 0.97 (0.74 to 1.28) | 0.98 (0.68 to 1.40) | 1.17 (0.99 to 1.38) |
| Adjusted for demographics, modifiable risk factors, and cardiac radiation exposure | 0.99 (0.89 to 1.10) | 0.90 (0.78 to 1.05) | 1.18 (0.85 to 1.63) | 1.02 (0.68 to 1.53) | 1.21 (1.03 to 1.43) |
| Adjusted for demographics, modifiable risk factors, and anthracycline exposure | 0.91 (0.82 to 1.02) | 0.79 (0.69 to 0.91) | 0.96 (0.75 to 1.24) | 0.97 (0.67 to 1.37) | 1.15 (0.96 to 1.38) |
| Adjusted for demographics, modifiable risk factors, and cardiotoxic exposures | 0.94 (0.83 to 1.05) | 0.87 (0.74 to 1.03) | 1.13 (0.83 to 1.53) | 0.99 (0.66 to 1.50) | 1.19 (0.99 to 1.43) |
Demographics=age at diagnosis, sex, race, body mass index, smoking, exercise intensity (metabolic hours/week); modifiable risk factors=diabetes, dyslipidemia, and hypertension; cardiotoxic exposures=cardiac radiation and anthracycline.