Table 8.

Rosiglitazone one stage meta-analyses

Outcome and data sources	Events/total population	Effect estimate (95% CI)
		Fixed effect	Random study specific effects*
Composite outcome
IPD	RSG: 274/11 837; control: 219/9319	1.39 (1.15 to 1.68)	1.39 (1.15 to 1.83)
Myocardial infarction
IPD	RSG: 147/11 837; control: 133/9319	1.27 (1.00 to 1.64)	1.27 (1.00 to 1.92)
IPD+summary	RSG: 190/24 467; control: 173/20 372	1.20 (0.97 to 1.49)	1.20 (0.96 to 1.51)
Heart failure
IPD	RSG: 122/11 837; control: 80/9319	1.64 (1.22 to 2.21)	1.64 (1.22 to 2.24)
Cardiovascular related deaths
IPD	RSG: 15/11 837; control: 10/9319	1.25 (0.56 to 2.92)	1.25 (0.46 to 2.92)
IPD+summary	RSG: 41/24 020; control: 30/19 908	1.22 (0.76 to 1.98)	1.22 (0.74 to 1.98)
Non-cardiovascular related deaths
IPD	RSG: 22/11 837; control: 13/9319	1.36 (0.69 to 2.84)	1.36 (0.61 to 2.83)

IPD=individual patient level data; RSG=rosiglitazone.

^*Simmonds and Higgin’s model with random study specific effects.