Table 3.
Prespecified subgroup meta-analyses of cardiovascular disease risk for one egg per day increase using random effects models
| Stratification and categories | No of risk estimates | No of participants | No of events | Pooled relative risk (95% CI) | I2 (%) | P for interaction |
|---|---|---|---|---|---|---|
| Region | ||||||
| US | 13 | 503 727 | 30 796 | 1.01 (0.96 to 1.06) | 30.8 | 0.07 |
| Europe | 10 | 531 234 | 18 299 | 1.05 (0.92 to 1.19) | 64.7 | — |
| Asia | 10 | 685 147 | 90 100 | 0.92 (0.85 to 0.99) | 44.8 | — |
| Sex | ||||||
| Both | 18 | 1 291 909 | 109 236 | 0.99 (0.91 to 1.08) | 77.0 | 0.89 |
| Men | 8 | 116 821 | 16 342 | 1.00 (0.94 to 1.06) | 21.2 | — |
| Women | 7 | 311 378 | 13 617 | 0.97 (0.90 to 1.04) | 0.0 | — |
| Follow-up duration | ||||||
| <10 years | 11 | 624 811 | 87 654 | 1.05 (0.87 to 1.27) | 70.8 | 0.43 |
| ≥10 years | 22 | 1 095 297 | 51 541 | 0.99 (0.95 to 1.03) | 35.9 | — |
| No of people | ||||||
| <10 000 | 16 | 67 924 | 7073 | 1.05 (0.94 to 1.17) | 45.7 | 0.15 |
| ≥10 000 | 17 | 1 652 184 | 132 122 | 0.96 (0.90 to 1.01) | 70.4 | — |
| No of events | ||||||
| <1000 | 19 | 214 735 | 6655 | 1.05 (0.95 to 1.17) | 41.5 | 0.13 |
| ≥1000 | 14 | 1 505 373 | 132 540 | 0.95 (0.90 to 1.01) | 75.0 | — |
| Risk of bias* | ||||||
| Low | 15 | 936 243 | 37 492 | 0.98 (0.94 to 1.02) | 0.0 | 0.99 |
| High | 18 | 783 865 | 101 703 | 0.99 (0.91 to 1.07) | 76.1 | — |
| Dietary assessment | ||||||
| Baseline only | 24 | 916 680 | 34 844 | 0.99 (0.93 to 1.05) | 52.0 | 0.56 |
| Repeated measurements | 9 | 803 428 | 104 351 | 0.97 (0.88 to 1.06) | 70.5 | — |
*
Newcastle-Ottawa scale score: low, ≥7; high, ≤6.