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. 2020 Apr 17;16(4):e1007768. doi: 10.1371/journal.pcbi.1007768

Table 2. Estimation of log hazard indirect effects: αkβk.

kk) = αkβk Estimation Cen = 15% Cen = 25% Cen = 35%
n = 300 n = 500 n = 1000 n = 300 n = 500 n = 1000 n = 300 n = 500 n = 1000
(0.5,0.55) = 0.275 Est.
CP
Emp. SE
Est. SE
0.2952
0.9238
0.0855
0.0794
0.2794
0.9220
0.0642
0.0584
0.2753
0.9360
0.0425
0.0405
0.2954
0.9173
0.0874
0.0805
0.2794
0.9400
0.0658
0.0590
0.2758
0.9320
0.0430
0.0410
0.2956
0.9004
0.0935
0.0815
0.2801
0.9420
0.0670
0.0600
0.2764
0.9360
0.0435
0.0416
(0.45,0.6) = 0.27 Est.
CP
Emp. SE
Est. SE
0.2916
0.9300
0.0892
0.0825
0.2806
0.9480
0.0616
0.0622
0.2716
0.9600
0.0417
0.0428
0.2930
0.9120
0.0954
0.0837
0.2821
0.9520
0.0636
0.0630
0.2717
0.9680
0.0419
0.0432
0.2930
0.9151
0.0981
0.0846
0.2827
0.9500
0.0647
0.0638
0.2719
0.9600
0.0424
0.0436
(0.5,0.65) = 0.325 Est.
CP
Emp. SE
Est. SE
0.3443
0.9358
0.0936
0.0902
0.3343
0.9380
0.0701
0.0677
0.3300
0.9600
0.0459
0.0467
0.3445
0.9196
0.0970
0.0912
0.3341
0.9380
0.0698
0.0683
0.3305
0.9480
0.0467
0.0472
0.3436
0.9295
0.0973
0.0921
0.3347
0.9480
0.0704
0.0692
0.3311
0.9520
0.0473
0.0477
(0.4,0.7) = 0.28 Est.
CP
Emp. SE
Est. SE
0.2975
0.9440
0.0959
0.0936
0.2889
0.9780
0.0641
0.0699
0.2813
0.9420
0.0479
0.0483
0.2978
0.9400
0.0990
0.0942
0.2897
0.9720
0.0654
0.0705
0.2814
0.9460
0.0483
0.0486
0.2982
0.9320
0.0988
0.0952
0.2896
0.9740
0.0664
0.0710
0.2815
0.9380
0.0485
0.0489
(0.45,0) = 0 Est.
CP
0.0078
0.5714
-
-
-
-
0.0167
0.3157
0.0514
0
-
-
0.0098
0.5384
0.0143
0
-
-
(0.45,0) = 0 Est.
CP
0.0327
0.1538
-0.0478
0
-
-
0.0393
0.2142
0.0860
0
-
-
0.0128
0.4736
-0.0485
0.5000
-
-
(0,0.5) = 0 Est.
CP
-0.0043
0.9621
0.0024
0.9620
0.0009
0.9520
-0.0051
0.9620
0.0024
0.9674
0.0009
0.9520
-0.0043
0.9631
0.0027
0.9708
0.0009
0.9520
(0,0.5) = 0 Est.
CP
-0.0013
0.9656
0.0011
0.9440
0.0035
0.9540
-0.0013
0.9661
0.0012
0.9433
0.0035
0.9540
-0.0006
0.9629
0.0008
0.9445
0.0035
0.9540
(0,0) = 0 Est.
CP
0.0382
1
-
-
-
-
0.0930
1
-
-
-
-
0.0621
1
-
-
-
-
(0,0) = 0 Est.
CP
-0.0027
1
-
-
-
-
-0.0136
1
-
-
-
-
-0.0737
1
-
-
-
-

*Est.: the mean of estimators; CP: coverage probability, the proportion of the replicates that the 95% confidence interval covers the true value of estimate; Emp. SE: empirical standard error calculated as the sample standard deviation of the estimates over all replicates; Est. SE: the average of the standard errors over all replicates;—means the not available value.